Mirtazapine: Uses, Dosage, Side Effects, Precautions, Drug Interaction, Overdoses, and Storage

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Drug Name: Mirtazapine
Brand Names: Remeron
Generic Name: Mirtazapine


Mirtazapine is an antidepressant. It is used to treat many types of depressive disorders and depression. It works by increasing certain types of activity in the brain that blocks out depressive emotions.

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How to use

Mirtazapine comes as either regular tablets or disintegrating tablets which are usually taken once per day before bedtime. Swallow regular tablets with a full glass of water. Disintegrating tablets should be handled with a dry hand, and then placed over the tongue until it disintegrates and can be swallowed with saliva. Do not split or crush disintegrating tablets. Once taken out of their original package, they cannot be stored.

Side Effects

Mirtazapine may cause some side effects which include drowsiness, dizziness, nausea, changes in appetite, dry mouth, and mild tremors. If these side effects become severe, contact your doctor immediately.

There are some rare but serious side effects that can occur. These include seizures, fevers, nose sores, mouth sores, chills, irregular heartbeat, and allergic reactions. If these happen, stop taking the medication and consult your doctor immediately.


Be sure to tell your doctor about any drugs or supplements that you are taking. Tell your doctor if you are allergic to Mirtazapine or some other medication. Also, tell your doctor if you have any history of manic-depressive disorders, blood problems, liver, kidney, or heart diseases or seizures.

Drug Interaction

Mirtazapine may be affected when taking monoamine oxidase inhibitors. Taking Mirtazapine while taking monoamine oxidase inhibitors may cause serious side effects. The effects of Mirtazapine may also be affected when taking other drugs that cause drowsiness, such as sedatives, antihistamines, and pain relievers. Your doctor may need to reduce or change your prescription dosage as required.


Symptoms of Mirtazapine overdose include drowsiness, fast heartbeats, confusion, and poor memory. In case of Mirtazapine overdose, seek emergency medical treatment.


Strenuous activities should be done carefully when taking Mirtazapine, since you may experience dizziness and fatigue while doing so. If it can be helped, avoid these activities. Great care should also be exercised while driving. Be careful about rising up quickly from a standing or lying position.

Also, it is advisable to minimize alcohol intake or stop drinking completely while you are taking Mirtazapine since drinking may further increase the effects of drowsiness and dizziness.

Missed Dose

Take the missed dose as soon as you remember it, but if it is almost time for your next dose, skip the previous dose and continue your regular dosing schedule. Do not take a double dose since this can be dangerous.

Important Note

This drug should not be used during pregnancy because it is still unknown whether or not it causes side effects in unborn children. If you become pregnant while taking Mirtazapine, contact your doctor immediately.

It is very dangerous for children under 18 years of age to take Mirtazapine since it can cause very dangerous side effects including a rise in the tendency of committing suicide. If Mirtazapine is prescribed for your child, talk with your doctor regarding his/her possible suicidal tendencies. Take note of the telltale signs of suicide and guard them properly.


Mirtazapine must be tightly sealed and kept at room temperature. Do not store it at places with excessive heat or places with excessive moisture (such as the bathroom). Keep it out of the reach of children.

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